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M9490047.TXT
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1994-09-03
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Document 0047
DOCN M9490047
TI Comparison of virulence of Mycobacterium avium complex (MAC) strains
isolated from AIDS and non-AIDS patients.
DT 9411
AU Reddy VM; Parikh K; Luna-Herrera J; Falkinham JO 3rd; Brown S;
Gangadharam PR; Mycobacteriology Research Laboratories, University of
Illinois; College of Medicine at Chicago.
SO Microb Pathog. 1994 Feb;16(2):121-30. Unique Identifier : AIDSLINE
MED/94322658
AB Mycobacterium avium complex (MAC) strains from AIDS and non-AIDS
patients and from the environment were studied for their colony
morphology and virulence in beige mice. The majority of the MAC isolates
from AIDS patients, in contrast to those from non-AIDS patients and the
environment, showed increased virulence. Similarly, the majority of the
MAC isolates from AIDS patients formed smooth transparent (ST) colonies,
whereas most of the non-AIDS isolates formed smooth opaque (SO) or
intermediate (IM) type of colonies. MAC isolates from the same AIDS
patient obtained at different times were found to be heterogenic with
respect to serotype, RFLP and glycolipid patterns, suggesting that these
patients might be infected with more than one strain of MAC.
DE Animal AIDS-Related Opportunistic Infections/*MICROBIOLOGY Colony
Count, Microbial Comparative Study Female Genotype Human Male Mice
Mice, Inbred C57BL Mycobacterium avium
Complex/CYTOLOGY/GENETICS/ISOLATION & PURIF/ *PATHOGENICITY
Mycobacterium avium-intracellulare Infection/*MICROBIOLOGY Phenotype
Support, U.S. Gov't, P.H.S. Virulence JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).